Polymeric Osteopontin Employs Integrin Α9β1 as a Receptor and Attracts Neutrophils by Presenting a De Novo Binding Site*
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چکیده
POLYMERIC OSTEOPONTIN EMPLOYS INTEGRIN α9β1 AS A RECEPTOR AND ATTRACTS NEUTROPHILS BY PRESENTING A DE NOVO BINDING SITE* Norihisa Nishimichi, Fumiko Higashikawa, Hiromi H. Kinoh, Yoshiko Tateishi, Haruo Matsuda, & Yasuyuki Yokosaki From Cell-Matrix Frontier Laboratory, Biomedical Research Unit, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551; Laboratory of Immunobiology, Department of Molecular and Applied Biosciences, Graduate School of Biosphere Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima, 739-8528; Health Administration Center, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan Running title: Polymeric osteopontin attracts neutrophils binding to α9β1 Address correspondence to: Yasuyuki Yokosaki, M.D., Ph.D., Cell-Matrix Frontier Laboratory, Biomedical Research Building 216, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan. Tel +81 82 257 1523; Fax +81 82 256 2376; E-mail: [email protected]
منابع مشابه
Increased expression levels of integrin α9β1 and CD11b on circulating neutrophils and elevated serum IL-17A in elderly aspiration pneumonia.
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